María Portocarrero Enríquez VI señora de Moguer y Villanueva del Fresno
- Marriage: Juan Pacheco I marqués de Villena about 1442
- Died: 1470
- Buried: Monasterio Jerónimo de Santa María del Parral, Segovia, Castille and Leon, Spain
 Noted events in her life were:
• Occupation: VI Señora de Moguer y Villanueva del Fresno.
María married Juan Pacheco I marqués de Villena, son of Alfonso Téllez Girón señor de Frechilla and María Pacheco II señora de Belmonte, about 1442. (Juan Pacheco I marqués de Villena was born in 1419 in Belmonte, Asturias, Spain, died on 4 Oct 1474 in Trujillo, Extremadura, Spain and was buried in Monasterio Jerónimo de Santa María del Parral, Segovia, Castille and Leon, Spain.)
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